Honestly, I think it comes down to your driving habits and where you drive (city or highway). Unless you're running FBO and max PSI, then I wouldn't think you'd get better MPGs. If its a fairly conservative tune, you might see 1 or 2 MPG gain.
With a canned tune and nothing else, I couldn't see why it would be possible. As long as it's on the "lowest" setting. But again, it's not going to be anything phenomenal.
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